Searchable abstracts of presentations at key conferences in endocrinology

ea0061cd1.2 | Case Discussions: complex clinical cases 1.0 | OU2019

Diabetes Intervention Accentuating Diet and Enhancing Metabolism (DIADEM-I): a randomised controlled trial to examine the impact of an intensive lifestyle intervention consisting of a low-energy diet and physical activity on body weight and metabolism in early type 2 diabetes mellitus: preliminary findings

Chagoury Odette , Zaghloul Hadeel , Taheri Shahrad , DIADEM-1 Study Team Shahrad

Introduction: Increasing evidence shows that type 2 diabetes mellitus (T2DM) could be reversible and that this is related to weight loss. Significant weight loss achieved through bariatric surgery or medically can result in diabetes remission. Diabetes remission is more likely to occur in those who are younger, have shorter duration of disease, and are on fewer diabetes medications. The impact of using a low energy formula-based diet in combination with physical activity on T2...

ea0061p007 | (1) | OU2019

25-hydoxy vitamin D and cardio-metabolic risk factors in obesity with early Type 2 Diabetes mellitus

Zaghloul Hadeel , Chagoury Odette , Taheri Shahrad , DIADEM-1 Study Team Shahrad

Introduction: Type 2 Diabetes Mellitus (T2DM) and obesity are a serious health challenge. Obesity and metabolic disorders are associated with cardiovascular risk. Several studies have suggested that low vitamin D status contributes to insulin resistance. This study aimed to explore vitamin D and its relationship with cardio-metabolic risk factors in those with early T2DM.Methods: Early T2DM subjects (N=139) with early T2DM, ≤ 3 years, were...

ea0061cd2.1 | Case Discussions: complex clinical cases 2.0 | OU2019

Factors related to Non-Alcoholic Fatty Liver Disease (NAFLD) measures in obese subjects with early Type 2 Diabetes mellitus

Zaghloul Hadeel , Chagoury Odette , McGowan Barbara , Taheri Shahrad , DIADEM-1 Study Team Shahrad

Introduction: T2DM (type 2 diabetes mellitus) appears to worsen the course of NAFLD (Non-Alcoholic Fatty Liver Disease) and NAFLD can make diabetes management more challenging. Long-term, NAFLD can lead to liver fibrosis, steatohepatitis, cirrhosis, and end-stage liver disease. This study aimed to examine factors associated with NAFLD measures in early T2DM.Methods: Subjects (n=144) with early T2DM (<=3 years) and obesity (BMI>=27 kg/m<s...